OPN –Revisited
Published: June 1, 2015 | DOI: https://doi.org/10.7860/JCDR/2015/.6111
Vijayanirmala Subramani, Muthukumar Thiyagarajan, N.Malathi, Sharada T. Rajan
1. Senior Lecturer, Department of Oral Pathology & Microbiology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai, India.
2. Associate Professor, Department of Anatomy, Sri Ramachandra University, Porur, Chennai, India.
3. Professor and Head, Department of Oral Pathology & Microbiology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai, India.
4. Reader, Department of Oral Pathology & Microbiology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai, India.
Correspondence
Dr. Vijayanirmala Subramani,
No.17, Plot no.12/1, III Main Road, Lakshmi Nagar, Porur, Chennai-116, India.
E-mail : Subramani.viji3@gmail.com
Osteopontin (OPN), a matrix extracellular glyco-phosphoprotein is found in various tissues such as epithelium lined tissues, kidney, bone and teeth .It is also detected in all body fluids including blood and breast milk. OPN plays role in a number of physiological and pathologic events such as cell adhesion, migration and cell survival, angiogenesis, apoptosis, inflammation and wound healing. This review summarizes the current data of the biological activities of OPN in the development of tumour, its progression and metastasis.
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